Latest news from Journal of Experimental & Clinical Cancer Research on 海角社区 en-us Copyright 2025 海角社区 115 31 / /images/newswise-logo-rss.gif /articles/chloride-intracellular-channel-1-activity-is-not-required-for-glioblastoma-development-but-its-inhibition-dictates-glioma-stem-cell-responsivity-to-novel-biguanide-derivatives/?sc=rsin /articles/chloride-intracellular-channel-1-activity-is-not-required-for-glioblastoma-development-but-its-inhibition-dictates-glioma-stem-cell-responsivity-to-novel-biguanide-derivatives/?sc=rsin Mon, 14 Feb 2022 08:00:27 EST Chloride intracellular channel-1 (CLIC1) activity controls glioblastoma proliferation. Metformin exerts antitumor effects in glioblastoma stem cells (GSCs) inhibiting CLIC1 activity, but its low potency hampers its translation in clinical settings. We聽... Journal of Experimental & Clinical Cancer Research