Latest news from Stem Cell Reports on 海角社区 en-us Copyright 2025 海角社区 115 31 / /images/newswise-logo-rss.gif /articles/investigating-the-feasibility-and-ethical-implications-of-phenotypic-screening-using-nbsp-stem-cell-derived-tissue-models-to-detect-and-manage-disease/?sc=rsin /articles/investigating-the-feasibility-and-ethical-implications-of-phenotypic-screening-using-nbsp-stem-cell-derived-tissue-models-to-detect-and-manage-disease/?sc=rsin Mon, 02 May 2022 08:00:42 EST Stem-cell-derived tissue models generated from sick people are being used to understand human development and disease, drug development, and drug screening. However, it is possible to detect disease phenotypes before a patient聽... Stem Cell Reports /articles/auxilin-regulates-intestinal-nbsp-stem-nbsp-cell-nbsp-proliferation-through-egfr/?sc=rsin /articles/auxilin-regulates-intestinal-nbsp-stem-nbsp-cell-nbsp-proliferation-through-egfr/?sc=rsin Fri, 22 Apr 2022 04:00:53 EST ... Importantly, we demonstrate that Aux interacts with EGFR and safeguards the activation of EGFR to maintain a proper聽stem 聽cell聽proliferation rate. Thus, our data uncover the underlying mechanism of Aux in聽stem 聽cell聽proliferation control and聽... Stem Cell Reports /articles/substance-p-neurokinin-1-receptor-pathway-blockade-ameliorates-limbal-nbsp-stem-cell-nbsp-deficiency-by-modulating-mtor-pathway-and-preventing-cell-senescence/?sc=rsin /articles/substance-p-neurokinin-1-receptor-pathway-blockade-ameliorates-limbal-nbsp-stem-cell-nbsp-deficiency-by-modulating-mtor-pathway-and-preventing-cell-senescence/?sc=rsin Thu, 31 Mar 2022 04:00:17 EST ... Autologous limbal聽stem聽cell聽transplantation is highly successful, but impossible in cases of complete bilateral聽stem聽cell聽deficiency. In these ... We found that a very low amount of聽stem聽cell-like cells remained 4 weeks after the聽stem聽cell聽deficiency model聽... Stem Cell Reports /articles/nk-cell-content-does-not-seem-to-influence-engraftment-in-ex-vivo-t-cell-depleted-haploidentical-nbsp-stem-cell-nbsp-transplantation/?sc=rsin /articles/nk-cell-content-does-not-seem-to-influence-engraftment-in-ex-vivo-t-cell-depleted-haploidentical-nbsp-stem-cell-nbsp-transplantation/?sc=rsin Tue, 15 Mar 2022 09:00:37 EST NK cell content does not seem to influence engraftment in ex vivo T cell depleted haploidentical聽stem聽cell聽tra ... usefulness of NK cellderived IFNg inhibition to favor engraftment in allogeneic hematopoietic聽stem聽cell聽transplantation (HSCT)聽... Stem Cell Reports /articles/leveraging-interacting-signaling-pathways-to-robustly-improve-the-quality-and-yield-of-human-pluripotent-nbsp-stem-cell-derived-hepatoblasts-and-hepatocytes/?sc=rsin /articles/leveraging-interacting-signaling-pathways-to-robustly-improve-the-quality-and-yield-of-human-pluripotent-nbsp-stem-cell-derived-hepatoblasts-and-hepatocytes/?sc=rsin Mon, 07 Feb 2022 03:00:25 EST Pluripotent聽stem聽cell聽(PSC)-derived hepatocyte-like cells (HLCs) have shown great potential as an alternative to primary human hepatocytes (PHHs) for in vitro modeling. Several differentiation protocols have been described to direct PSCs toward the聽... Stem Cell Reports /articles/reaching-into-the-toolbox-nbsp-stem-cell-nbsp-models-to-study-neuropsychiatric-disorders/?sc=rsin /articles/reaching-into-the-toolbox-nbsp-stem-cell-nbsp-models-to-study-neuropsychiatric-disorders/?sc=rsin Mon, 24 Jan 2022 08:55:47 EST ... This review provides an overview of聽stem聽cell-based disease models in neuropsychiatry and considers the advantages and challenges surrounding the contributions ... Summary of the key elements and challenges for each聽stem-cell-based聽... Stem Cell Reports /articles/restoration-of-hippocampal-neural-precursor-function-by-ablation-of-senescent-cells-in-the-aging-nbsp-stem-cell-nbsp-niche/?sc=rsin /articles/restoration-of-hippocampal-neural-precursor-function-by-ablation-of-senescent-cells-in-the-aging-nbsp-stem-cell-nbsp-niche/?sc=rsin Mon, 24 Jan 2022 08:55:01 EST ... ) to ask if this is because senescent cells in聽stem聽cell聽niches impair precursor-mediated tissue maintenance. We demonstrate an aging-dependent accumulation of senescent cells, largely senescent NPCs, within the hippocampal聽stem聽cell聽niche聽... Stem Cell Reports /articles/4d-imaging-analysis-of-the-aging-mouse-neural-nbsp-stem-cell-nbsp-niche-reveals-a-dramatic-loss-of-progenitor-cell-dynamism-regulated-by-the-rho-rock-pathway/?sc=rsin /articles/4d-imaging-analysis-of-the-aging-mouse-neural-nbsp-stem-cell-nbsp-niche-reveals-a-dramatic-loss-of-progenitor-cell-dynamism-regulated-by-the-rho-rock-pathway/?sc=rsin Mon, 17 Jan 2022 08:55:24 EST Stem Cell Reports /articles/cell-position-within-human-pluripotent-nbsp-stem-cell-nbsp-colonies-determines-apical-specialization-via-an-actin-cytoskeleton-based-mechanism/?sc=rsin /articles/cell-position-within-human-pluripotent-nbsp-stem-cell-nbsp-colonies-determines-apical-specialization-via-an-actin-cytoskeleton-based-mechanism/?sc=rsin Tue, 21 Dec 2021 02:00:28 EST Human pluripotent stem cells (hPSCs) grow as colonies with epithelial-like features including cell polarity and position-dependent features that contribute to symmetry breaking during development. Our study provides evidence that hPSC colonies聽... Stem Cell Reports