�� Curated �� Channel: Journal of Experimental Medicine

UTSW Scientists Identify Cancer-Suppressing Genetic Mutation

UT Southwestern Medical Center — Mon, 23 Dec 2024 17:15:43 EST

UT Southwestern Medical Center researchers identified a genetic mutation that slows the growth of melanoma and potentially other cancers by harnessing the power of the immune system. Their findings, published in the Journal of Experimental Medicine, could lead to new treatments that improve outcomes from existing cancer immunotherapies.

Immune cells have a metabolic backup plan for accessing their anti-cancer playbook

Van Andel Institute — Fri, 23 Aug 2024 10:05:45 EST

Immune cells use two different routes to produce acetyl-CoA, an essential metabolite required to fight infection and cancer, reports a study led by Van Andel Institute scientists.

Master autoimmune regulator gets by with a little help from its friends

St. Jude Children's Research Hospital — Thu, 27 Jun 2024 13:05:46 EST

See how St. Jude researchers investigated Foxp3 function as a transcription cofactor in regulatory T cells in immune system activation and suppression.

Mutations protected mice from B-cell cancers

UT Southwestern Medical Center — Tue, 14 May 2024 15:05:28 EST

By completely or even partially depleting a protein called midnolin in B cells, UT Southwestern Medical Center researchers suppressed leukemia and lymphoma in a mouse model genetically prone to these cancers. Their findings, reported in the Journal of Experimental Medicine, could lead to new treatments for these diseases that avoid the serious side effects of current therapies.

Researchers identify new way to inhibit immune cells that drive allergic asthma

The Rockefeller University Press — Tue, 26 Mar 2024 10:00:00 EST

Researchers at the Keck School of Medicine, University of Southern California, have discovered that a protein called Piezo1 prevents a type of immune cell in the lung from becoming hyperactivated by allergens.

Newly identified yeast could prevent fungal infections by outcompeting rivals, study suggests

The Rockefeller University Press — Mon, 18 Mar 2024 10:00:00 EST

Researchers at the Weizmann Institute of Science in Israel have identified a yeast that could be used to prevent invasive candidiasis, a major cause of death in hospitalized and immunocompromised patients. The study, to be published March 18 in the Journal of Experimental Medicine (JEM), shows that the novel yeast lives harmlessly in the intestines of mice and humans and can displace the yeast responsible for candidiasis, Candida albicans.

Turbocharging CRISPR to Understand How the Immune System Fights Cancer

Harvard Medical School — Thu, 29 Feb 2024 08:00:02 EST

Harvard Medical School scientists develop new CRISPR-based tool to study the immune function of genes. New gene-editing approach could optimize how scientists study the immune system's role in cancer and other immune-mediated diseases.

Study identifies new pathway to suppressing autoimmunity

The Rockefeller University Press — Fri, 29 Sep 2023 10:00:00 EST

Researchers at Stanford University School of Medicine, Yale University School of Medicine, and the Hospital for Special Surgery Research Institute have uncovered new details about how the immune system prevents the production of antibodies that can recognize and damage the body's own, healthy tissues. The study, to be published September 29 in the Journal of Experimental Medicine (JEM), also reveals how this process is impaired in autoimmune disorders such as systemic sclerosis and systemic lupus erythematosus and suggests potential new strategies to treat these diseases.

Treating NASH disease by removing cholesterol from macrophages using a unique supramolecule

Nagoya University — Tue, 19 Sep 2023 14:05:22 EST

A research group from the Graduate School of Medicine and Research Institute of Environmental Medicine at Nagoya University reported that cholesterol accumulation in macrophages promotes liver fibrosis in the development of non-alcoholic steatohepatitis (NASH).

Training immune cells to remove 'trash' helps resolve lung inflammation

University of Illinois Chicago — Thu, 24 Aug 2023 11:05:40 EST

Acute lung injury occurs when our lung's immune system response becomes hyperactivated and causes inflammation to continue unchecked. In fact, many deaths from COVID-19 were from acute lung injury.

Mutations in blood stem cells can exacerbate colon cancer

The Rockefeller University Press — Thu, 24 Aug 2023 10:00:00 EST

Researchers at the University of Florida College of Medicine have discovered how common age-related changes in the blood system can make certain colon cancers grow faster.

Neuroscientists create new resource to improve Alzheimer's disease research models

Indiana University — Wed, 23 Aug 2023 07:30:41 EST

A new study by Indiana University School of Medicine researchers uses more genetically diverse mouse models to study the accumulation and spread of abnormal tau protein deposits in the brain.

Researchers Identify a New Mechanism, Cancer Hijacks Enzyme Substrate Motif Mutations

University of North Carolina School of Medicine — Mon, 03 Jul 2023 15:05:11 EST

Enzyme mutations have been of great interest to scientists who study cancer. Scientists in the Liu and Tan labs at UNC's Lineberger Comprehensive Cancer Center have been studying mutations of enzyme recognition motifs in substrates, which may more faithfully reflect enzyme function with the potential to find new targets or directions for cancer treatment.

Researchers Use 'Natural' System to Identify Proteins Most Useful For Developing an Effective HIV Vaccine

Johns Hopkins Medicine — Tue, 30 May 2023 14:00:35 EST

Scientists have spent years trying to develop an effective HIV vaccine, but none have proven successful. Based on findings from a recently published study, a Johns Hopkins Medicine-led research team may have put science one step closer to that goal.

Researchers discover how some brain cells transfer material to neurons in mice

UC Davis Health — Mon, 17 Apr 2023 15:35:35 EST

A UC Davis study is the first to report on a material transfer mechanism from cells, known as oligodendrocytes, to neurons in the brain of a mouse model. This discovery opens new possibilities for understanding brain maturation and finding treatments for many neurological conditions.

Study to decode microbe-gut signaling suggests potential new treatment for IBD

Cincinnati Children's Hospital Medical Center — Tue, 04 Apr 2023 13:00:08 EST

Fresh insights into how our bodies interact with the microbes living in our guts suggest that a two-drug combination may offer a new way to treat inflammatory bowel diseases such as Crohn's disease and ulcerative colitis.

Can Controlling Retinoic Acid be a Key to Preventing Infections in the Gut?

Stony Brook University — Tue, 28 Mar 2023 13:55:19 EST

A team of scientists from the Renaissance School of Medicine (RSOM) at Stony Brook University have identified a distinct role of retinoic acid, a metabolite of vitamin A, during the immune response of the gut.

Insights into causes of rare genetic immune disorders

Garvan Institute of Medical Research — Tue, 21 Mar 2023 15:55:01 EST

The cellular glitches underlying a rare genetic disorder called activated PI3K Delta syndrome 2 (APDS2) have been identified by researchers at the Garvan Institute of Medical Research.

New gene-editing technique reverses vision loss in mice

The Rockefeller University Press — Fri, 17 Mar 2023 10:00:00 EST

Researchers in China have successfully restored the vision of mice with retinitis pigmentosa, one of the major causes of blindness in humans. The study, to be published March 17 in the Journal of Experimental Medicine, uses a new, highly versatile form of CRISPR-based genome editing with the potential to correct a wide variety of disease-causing genetic mutations.

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